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KMID : 0043320110340101605
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Archives of Pharmacal Research
2011 Volume.34 No. 10 p.1605 ~ p.1614
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Synthesis of novel quinoxalinone derivatives by conventional and microwave methods and assessing their biological activity
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Nasir Waqar
Munawar Munawar Ali
Ahmed Ejaz
Sharif Ahsan
Ahmed Saeed
Ayub Amjad
Khan Misbahul Ain
Nasim Faizul Hassan
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Abstract
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In this study, twenty-one arylaminoquinoxalinone derivatives were synthesized and their antibacterial activities against Staphylococci aureus, Pseudomonas aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Shigella pneumoniae were evaluated relative to known antibiotics; augmentin, ampicillin, and chloramphenicol. The insecticidal activities of the prepared compounds were also investigated against Tribolium castaneum using permethrin as a standard insecticide. The derivatives were synthesized using both conventional and microwave techniques. Their structures were confirmed using spectral techniques and elemental analysis.
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KEYWORD
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3,4-Dihydroquinoxalin-2(1H)-one, 4-(Chloroacetyl)-3,4-dihydroquinoxaline-2(1H)-one, Antibacterial, Insecticidal, Phytotoxic
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